Child Aid Association (CAA) is a registered voluntary organization with the Department of Social Welfare Government of Sindh which was founded in 1979. The activities of the Association are governed by an elected executive committee, and its finances are audited by M/s. Muniff Ziauddin & Co., chartered accountants. The objective of the Association initially was to provide underprivileged children free medicines and help with special investigations, which were not available at NICH. Over time, life support systems and other equipment for intensive care have also been provided to facilitate complicated surgeries.

Having established the first pediatric Cancer Center in Pakistan in 1999 at NICH, the Association is providing free treatment to all patients. Till 30th June 2025, over 11,500 children have been treated, coming from all over Pakistan and neighboring countries. The Cancer Center has achieved 70% disease free survival in those who completed treatment as per international protocols.

In 2007 a Cytogenetic Laboratory was stablished at the NICH with the assistance of Association of Physicians of Pakistani origin North America (APPNA), Rotary Club, Sunset Millennium, Karachi and many other local donors. A molecular lab was also commissioned in 2009, with the assistance of Pakistan Bait-ul-Mal and with the cooperation of Rotary Club, Sunset Millennium. The lab not only provides services to cancer patients, but also patients of endocrinology at NICH and outside. A Total Parental Nutrition (TPN) lab was established in 2011 sponsored by Infaq Foundation and open for NICH as well as outside patients.